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Remove Northeastern South Carolina History Trail Clio Historic District Downtown and Red Bluff Street, Clio SC Overview: Once the center of northeastern Marlboro County's cotton country, the small town of Clio offers drive-by visitors a remarkable collection of residential architectural styles from the late 19th and early 20th century. Early Cotton Press Highway 38, Latta SC Overview: Located adjacent to S.C. Highway 38, near Interstate 95 Exit 181A, near the town of Latta, the Early Cotton Press may be the oldest, original cotton press in the United States. While on private property, it may be viewed from a highway pullout.