An ancient pre-Columbian Native-American historic site, the Sewee Shell Mound is accessed by a hiking trail in Francis Marion National Forest. Visitors may begin their tour at the Sewee Visitor and Environmental Education Center, located at 5821 U.S. 17 North, in the town of Awendaw.

The oldest museum in the United States, the Charleston Museum was established in 1773. Its numerous exhibits, displays and artifacts survey South Carolina's rich history and culture.

A 2,725-acre preserve and wildlife area, the Great Pee Dee River Heritage Preserve and Wildlife Management Area preserves a seven-mile stretch of the historic Great Pee Dee River in its natural state. It is managed by the S.C. Department of Natural Resources.

The Horry County Museum is located on Main Street, in downtown Conway, and features a variety of well-designed exhibits that chronicle the colorful history of Horry County. Permanent exhibits focus on local Native American culture, the timber industry and naval stores operations.

Poinsett State Park, with its mixed natural ecosystems, pre-revolutionary grist mill ruins, rustic cabins, a 10-acre lake, campsites, hiking and equestrian trails, fishing ponds with coquina bathhouse built by the Civilian Conservation Corps in the 1930's makes for a serene setting for nature lovers.

Seaside Farms is the home of infamous bootlegger John Long. Long made great amounts of money using the inlets around Isle of Palms, Sullivan's Island, Dewees Island, and Mt. Pleasant to import illegal booze during the imposition of The Volstead Act (Prohibition).

Historical exhibits and artifacts ranging from the prehistoric to the present are displayed at the Florence Museum, including extensive collections of art. Among the highlights: the Francis A. Lord Collection of Civil War Artifacts, exhibits on local and South Carolina history, the World War Hall, artifacts and displays related to slavery and African American culture, and ancient art and artifacts from throughout the world.

Managed by the U.S. Fish and Wildlife Service, Waccamaw National Wildlife Refuge is composed of 54,000 acres of undeveloped land on the Waccamaw, Great Pee Dee and Little Pee Dee Rivers, with a state-of-the-art nature center overlooking Yauhannah Lake on the Great Pee Dee River off U.S. 701, approximately 15 miles south of Conway.

1,100 acres showcase one the finest Arabian horse facilities in the states with boarding, shows, lessons and an indoor arena.